Pubblicato su stage4eu il: 23/02/2021 Roche, Student Internship in Protein Science

Roche Pharmaceuticals
Grenzacherstrasse 124, Basel, Svizzera
6 mesi. Inizio: aprile-maggio 2021 
Posti disponibili Non specificato
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The Lead Discovery Department in Small Molecule Research is part of Therapeutic Modalities (TMo) within Roche Pharma Research and Early Development (pRED). We deliver leading edge science to drive the success of Roche’s early pipeline discovery research activities through a strong expertise in high throughput or focused screening platforms, DNA encoded library technology, protein science & enzymology/biophysics, cell-based assays and screening and biostructure determination. We are accountable for the provision of high quality chemistry starting points for Small Molecule projects and generating molecular and mechanistic insights that are critical for the advancement of discovery projects. 


During the internship, you will:

  • Actively contribute to an early-stage drug discovery research project by performing protein purifications 
  • Optimize protein sample quality for cryo-EM structure determination
  • Learn a broad spectrum of methods to characterize the stability and enzymatic activity of proteins, and analyze interactions with small-molecule ligands
  • Get hands-on experience on laboratory automation and robotics 
  • Plan experiments and present your findings in group seminars
  • Learn about the function of a research department in the pharmaceutical industry
Requisiti principali:


As an enthusiastic and proactive Master student in the area of biochemistry or related fields with prior experimental know-how in protein purification and characterization, you are highly motivated, interested in a multidisciplinary and multinational environment and you wish to expand your technical skills in the laboratory. 


We are looking for an aspiring scientist with:

  • Good knowledge and technical experience in molecular biology (cloning, construct design, protein expression strategies)
  • Technical experience in protein purification and analytical methods such as affinity or size exclusion chromatography and SDS-PAGE.
  • Structure determination experience and general education in protein structure are a plus 
  • Excellent organizational skills and a pro-active attitude 
  • Motivated and focused, able to multitask, and meets timelines efficiently and productively
  • Fluent in English (German is a plus)
  • Master of Science student (M.Sc.) with proof of academic excellence and currently enrolled in a University or recently graduated (not longer than 12 month ago) with the goal to pursue a career in the Life Sciences field
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